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Research Assistant II

Drexel University
Pennsylvania, United States
Salary Not Specified
Posted Date
Jan 20, 2022

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Position Type
Faculty Positions, Science, Technology & Mathematics, Biology & Life Sciences, Biotechnology & Bioengineering, Chemistry & Biochemistry, Administrative, Academic Affairs, Research Administration
Employment Type
Full Time
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About Drexel

Drexel is a comprehensive global research university ranked among the top 100 in the nation. With over 24,000 students, Drexel is one of America's 15 largest private universities. Drexel is one of Philadelphia's top 10 private employers, and a major engine for economic development in the region. Drexel has committed to being the nation’s most civically engaged university, with community partnerships integrated into every aspect of service and academics.

Job Summary

The Chaiken Laboratory at Drexel University seeks a Research Assistant, with strong hands-on experience in protein chemistry, biochemistry and molecular biology, to support a research program that investigates molecular and structural mechanisms and antagonism of the envelope protein complexes of HIV-1 and SARS-CoV-2. Our Group has recently discovered molecular strategies to irreversibly inactivate Env and functionally kill both the virus and virus-expressing cells. The Research Assistant will integrate into and be part of the Laboratory's broad-based research environment that encompasses identification of recombinant and synthetic antagonists, and the use of chemical and molecular biology, biophysical methods and physical virology approaches to drive investigations of structure-based antagonism of Env. The position will include helping to produce and utilize synthetic peptides, recombinant proteins and pseudoviruses, and their site-directed variants, and analyses of the sensitivity of Env to inactivators and antagonists using molecular, biophysical, and cell-based functional analyses.

Essential Functions
  • Recombinant protein purification (mammalian and bacterial expression, FPLC, affinity purification)
  • Molecular Biology (PCR, cloning, site-directed mutagenesis, DNA isolation)
  • Biochemical analyses (Western blotting, ELISA, SPR biosensor and other molecular binding methods)
  • Tissue culture (cell lines / primary cells)
  • Purification and characterization of recombinant viruses
  • Preparation, chromatographic purification, and characterization of synthetic peptide-based inhibitors
  • Cellular and virological assays
  • Operation of standard research lab equipment, and computer hardware and software
Required Qualifications
  • Bachelor's Degree in Biochemistry, Chemical Biology and Molecular Biology, or closely related field
  • Minimum of 1 year laboratory research experience
  • Operation of standard research lab equipment, and computer hardware and software
Preferred Qualifications
  • Master’s Degree, Biochemistry and Molecular Biology, or closely related field
  • Hands-on experience for essential functions will be preferred.

Center City, Philadelphia, PA

Additional Information

This position is classified as Exempt with a salary grade of H. For more information regarding Drexel’s Professional Staff salary structure,

Special Instructions to the Applicant

Please make sure you upload your CV/resume and cover letter when submitting your application.

Review of applicants will begin once a suitable candidate pool is identified.

Advertised:Jan 20 2022 Eastern Standard Time
Applications close:Feb 21 2022 Eastern Standard Time

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