Lab Specialist - Pathology

Lab Specialist - Pathology

Job Summary

JOB SUMMARY
The Matt Bettini Lab in the Department of Pathology has an immediate opening for a Lab Specialist who shares our vision for excellence in immunology research. The position will be based at the University of Utah School of Medicine, ranked among the top 30 public research universities in the nation, located in the foothills overlooking Salt Lake City.

The focus of the available project within the broader research program is to study the role of ITAM number and sequence in Chimeric Antigen Receptor (CAR) T cell function. The Lab Specialist will have an opportunity to train in cutting edge technologies and the use of humanized mouse models.

The Lab Specialist will contribute to projects understanding the transcriptional regulation and CAR signaling signatures of human CAR T cells in various tumor antigen models. A preferred applicant will be familiar with one or more of the following techniques: NRG/NSG mouse models and human CAR T cell generation, flow cytometry, western and IP western blots, use of next-generation single cell RNA sequencing, omics analysis including phosphoproteomics and metabolomics.

A minor component of this position will include maintenance, breeding, and genotyping a number of genetically modified mouse strains. The ideal applicant should be self-motivated and have good record keeping and time management skills. Mouse husbandry includes maintenance, breeding, genotyping of mouse colony.

Excellent training opportunity for students interested in pursuing a career in science, including graduate and medical school.

For more information regarding the job posting, you may contact Dr. Bettini at matt.bettini@path.utah.edu, or visit https://www.bettini-lab.org.

Responsibilities
ESSENTIAL FUNCTIONS

1. Performs and/or directs the performance of standard and complex lab tests and experiments and/or surgical procedures for studies.
2. Assists the Principal Investigator in the design, implementation and performance of new protocols and procedures as well as the modification of existing techniques.
3. Reviews scientific journals, abstracts and other literature for information concerning experimental procedures.
4. Makes advanced statistical calculations, analyzes data and prepares reports summarizing research results.
5. Operates complex and highly specialized laboratory and surgical instruments and equipment. Instructs others in their use.
6. Maintains a log of supplies used in procedures.
7. May supervise, train and review the work of laboratory personnel.
8. May prepare equipment and rooms for studies.
9. May assist with preparing budgets.
   
   

This is an NIH-funded position. Our laboratory uses state of the art approaches to interrogate how CAR ITAM sequences dictates function.

This position will give you the unique chance to actively drive research projects taking a systems biology approach for understanding CAR T cell function.
The successful candidate will be involved in the development of experimental design, data collection, and analysis. Projects will involve collaborations with colleagues at the University of Utah as well as those at other institutions.
This job description is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.
Work Environment and Level of Frequency that may be required: Nearly Continuously: Laboratory environment.Often: Data entry of results from genetic testing, laboratory upkeep, ordering of supplies.Often: Exposure to animals.
Physical Requirements and Level of Frequency that may be required Nearly Continuously: Hearing, listening, talking.Often: Repetitive hand motion (such as typing and pipetting), walking, standing, sitting.Seldom: Bending, reaching overhead.

Minimum Qualifications
Bachelor's degree in Biology, Chemistry or other scientific discipline or equivalency (one year of education can be substituted for two years of related work experience); two years full-time laboratory experience; and demonstrated human relations and effective communication skills required. Working knowledge of advanced scientific techniques and procedures as well as the ability to make statistical calculations, analyze results, prepare reports and perform specialized tests also required.

Applicants must demonstrate the potential ability to perform the essential functions of the job as outlined in the position description.

Preferences
PREFERENCES

• Applicants with expertise in CAR T cell immunology including the use of NSG/NRG mice, flow cytometry, confocal imaging, cell culture, and next generation sequencing and omics analysis are preferred.
• The ideal candidate has strong writing and organizational skills and enjoys working in a collaborative and multidisciplinary team.
• Familiarity with molecular techniques such as PCR, Flow cytometry, cell culture and general Immunology.
• Previous mouse handling.

Special Instructions
Start date for this position is after November 1, 2024.

Requisition Number: PRN40165B
Full Time or Part Time? Full Time
Work Schedule Summary: 40 hours per week. Monday - Friday, 8am - 5pm (with one-hour unpaid lunch). Required on-site.Referencing a 40-hour work week, approximately 30 hours will be dedicated to cell culture/CAR T cell generation and Data Entry. The remaining 10 hours will be dedicated to laboratory maintenance, DNA isolation, PCR analysis and data entry, and helping with ongoing experiments when necessary.
Department: 00247 - Pathology
Location: Campus
Pay Rate Range: 15.19 to 26.73
Close Date: 1/22/2025
Open Until Filled:

To apply, visit https://utah.peopleadmin.com/postings/173075


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