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Postdoctoral Researcher Mechanisms and applications of bacterial immune systems Santiago-Frangos

University of Pennsylvania
Pennsylvania, United States
Salary Not specified
Date posted
Jan 29, 2024

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Postdoctoral Researcher Mechanisms and applications of bacterial immune systems Santiago-Frangos Lab

Location: Philadelphia, PA
Open Date: Jan 29, 2024

The Santiago-Frangos lab seeks a motivated and enthusiastic postdoctoral fellow to work in a multidisciplinary team on cutting edge research that determines how immune systems (e.g. CRISPR) function, and that repurposes these mechanistic insights for biotech applications. Relevant research includes our papers published in NSMB and Nat. Comms., and a patent on a CRISPR-based diagnostic. More info can be found at:

The postdoctoral fellow will have the opportunity to work on up to two research arms in the lab, that aim to determine how i) bacterial and archaeal CRISPR adaptive immune systems make DNA-based memories of past phage infections, and ii) how CRISPR-generated nucleotide messengers signal an immune response. Candidates interested in biotech applications of CRISPR-mediated immunity are also invited to apply.

Project scope will be tuned to the fellow's interests and skills. Broadly: i) Use a combination of sequence- and structure-based comparative approaches to discover novel biochemical activities and biological functions, or ii) develop biochemical assays to test bioinformatics-based hypotheses, and determine the structures of large protein and protein-nucleic acid complexes using cryo-EM.

Lab and Institution Overview

The Santiago-Frangos lab integrates bioinformatics, biochemistry, and structural biology to address complex biological and biotechnological questions ( The Santiago-Frangos lab values Curiosity, Open communication, Integrity, a Growth mindset, and Diversity, Equity and Inclusion. We are located in a large and newly renovated (2024) space at Leidy Labs within the Biology Department at the University of Pennsylvania (UPenn). Research in the Santiago-Frangos lab is supported by the NIH and the Burroughs Wellcome Fund.

All UPenn schools are located on a single compact campus, with no laboratory or faculty office more than a 12-minute walk away - fostering a multidisciplinary approach to education, scholarship, and research. Candidates will have access to many well-funded and equipped core research facilities including: Cryo-Electron Microscopy Facility, Bioinformatics Core, High-Throughput Screening Core, Johnson Foundation Biophysical Structural Biology Core, The Biological Chemistry Resource Center, and the Penn Microbial Culture and Metabolomics Core.

Postdoctoral Fellow Responsibilities:
  • Use bioinformatic, biochemical and/or structural biology approaches to study open research questions in the lab.
  • Develop new research directions under close mentorship from Dr. Santiago-Frangos.
  • Communicate their work with the scientific community via presentations and publications.
  • Maintain a detailed electronic lab notebook that can be shared as needed with lab members and collaborators.
  • Actively participate in their own personal and professional development.
  • Collaborate with lab members and train mentees.
  • Apply for independent funding.
  • Contribute their unique expertise to the lab.

Minimum Qualifications:
  • Ph.D. degree in biology, biochemistry, biophysics, structural biology, bioinformatics, microbiology, or related.
  • One published first-author research paper in a peer-reviewed journal.
  • Excellent written and verbal communication skills.
  • Independently motivated to develop, conduct, analyze and document research experiments and results.

Postdoctoral Fellows Receive a minimum stipend of $65,000.

Enrolling in benefits through UPenn will give the postdoc a full array of support and services that include:

Medical, dental, vision, and life insurance; Retirement benefits; Sick Leave; New Child Leave; Employee assistance program; Fertility benefits; Pre-tax accounts; Commuter and parking programs; Short-term and long-term disability insurance; Wellness programs. (see:

Application Instructions
Please submit your CV, three letters of reference, and a cover letter. Your cover letter should summarize your doctoral research, your research interests, why you are interested in joining our lab, and your short and long term career goals.

To apply, visit

The University of Pennsylvania values diversity and seeks talented students, faculty and staff from diverse backgrounds. The University of Pennsylvania is an equal opportunity and affirmative action employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status or any other legally protected class. Questions or concerns about this should be directed to the Executive Director of the Office of Affirmative Action and Equal Opportunity Programs, University of Pennsylvania, 421 Franklin Building, 3451 Walnut Street, Philadelphia, PA 19104-6205; or (215) 898-6993 (Voice) or (215) 898-7803 (TDD).

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