Director, Clinical Development (Gene Therapy Program)
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Posted Job Title
Director, Clinical Development (Gene Therapy Program)
Job Profile Title
Director D, Research
Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of
unprecedented opportunity with the great potential to reshape the
face of medicine. Our discoveries have set the stage for successful
treatments and possibly even cures for devastating genetic
diseases. GTP is a complex R&D organization consisting of
research laboratories and multiple core functions which provide
internal capacity to perform gene transfer studies from basic
research through clinical trials.
The laboratory of Dr. Jim Wilson at the GTP of the University of
Pennsylvania has been a leader in the development of innovative
vector technology for three decades. We have emerged as the "go-to"
organization for public and private partners, who want to
participate in the gene therapy space. Currently we are positioned
to lead another round of vector innovation and establish
preclinical and clinical proof-of-concept in therapeutic
applications of in-vivo genetic therapies.
Continuation of all GTP positions is contingent upon funding.
Our genetic therapy programs involve multiple clinical indications
including neuromuscular, cardiovascular, oncology, metabolic, and
We are currently seeking a Clinical Development Director to be
responsible for the scientific and clinical strategy for several
gene therapy programs under the leadership of the Chief Medical
This position will work in close collaboration with multiple
functional groups at GTP especially the Translational, CMC, and
Regulatory teams as well as with the Penn Orphan Disease Center.
You will be responsible for clinical development plans, clinical
protocols, and clinical aspects of regulatory interactions
providing scientific and technical input on clinical studies
including disease assessment, study design, study conduct, data
analysis, and interpretation. In addition to study
conceptualization and protocol development in collaboration with
the larger program team, you will provide cross-functional support
to clinical operations on the trial execution strategy as well as
CRO, site, and vendor selection. You will also provide regular
scientific support for ongoing clinical trials including natural
history studies and patient registries that will support gene
You will develop an external key opinion leader network and
relationships with patient advocacy groups to bring scientific,
patient, and medical expert insight to our research programs. You
will also contribute to the organization of and participation in
external Advisory board meetings and Orphan Disease think
Job Location - City, State
- Bachelor's Degree and minimum of 7 to 10 years of clinical
trial experience in the pharmaceutical/biotech industry or
equivalent environment is required. M.S. or Ph.D. or equivalent
degree is preferred but not required.
- Experience with clinical protocol development
- Experience with writing clinical protocols, clinical sections
of regulatory documents is required.
- Experience with clinical trial management preferred.
- Experience with clinical trial data cleaning, data analysis,
and data presentation is preferred.
Department / School
Perelman School of Medicine
$90,860.00 - $200,000.00 Annual Rate
Salary offers are made based on the candidate's qualifications,
experience, skills, and education as they directly relate to the
requirements of the position, as well as internal and market
factors and grade profile.
Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis
of race, color, sex, sexual orientation, gender identity, religion,
creed, national or ethnic origin, citizenship status, age,
disability, veteran status, or any other legally protected
Background check required after a conditional job offer is made.
Consideration of the background check will be tailored to the
requirements of the job.
- Health, Life, and Flexible Spending Accounts: Penn
offers comprehensive medical, prescription, behavioral health,
dental, vision, and life insurance benefits to protect you and your
family's health and welfare. You can also use flexible spending
accounts to pay for eligible health care and dependent care
expenses with pre-tax dollars.
- Tuition: Take advantage of Penn's exceptional tuition
benefits. You, your spouse, and your dependent children can get
tuition assistance here at Penn. Your dependent children are also
eligible for tuition assistance at other institutions.
- Retirement: Penn offers generous retirement plans to
help you save for your future. Penn's Basic, Matching, and
Supplemental retirement plans allow you to save for retirement on a
pre-tax or Roth basis. Choose from a wide variety of investment
options through TIAA and Vanguard.
- Time Away from Work: Penn provides you with a
substantial amount of time away from work during the course of the
year. This allows you to relax, take vacations, attend to personal
affairs, recover from illness or injury, spend time with
family—whatever your personal needs may be.
- Long-Term Care Insurance: In partnership with Genworth
Financial, Penn offers faculty and staff (and your eligible family
members) long-term care insurance to help you cover some of the
costs of long-term care services received at home, in the community
or in a nursing facility. If you apply when you're newly hired, you
won't have to provide proof of good health or be subject to
underwriting requirements. Eligible family members must always
provide proof of good health and are subject to
- Wellness and Work-life Resources: Penn is committed to
supporting our faculty and staff as they balance the competing
demands of work and personal life. That's why we offer a wide
variety of programs and resources to help you care for your health,
your family, and your work-life balance.
- Professional and Personal Development: Penn provides an
array of resources to help you advance yourself personally and
- University Resources: As a member of the Penn community,
you have access to a wide range of University resources as well as
cultural and recreational activities. Take advantage of the
University's libraries and athletic facilities, or visit our
arboretum and art galleries. There's always something going on at
Penn, whether it's a new exhibit at the Penn Museum, the latest
music or theater presentation at the Annenberg Center, or the Penn
Relays at Franklin Field to name just a few examples. As a member
of the Penn community, you're right in the middle of the
excitement—and you and your family can enjoy many of these
activities for free.
- Discounts and Special Services: From arts and
entertainment to transportation and mortgages, you'll find great
deals for University faculty and staff. Not only do Penn arts and
cultural centers and museums offer free and discounted admission
and memberships to faculty and staff. You can also enjoy
substantial savings on other goods and services such as new cars
from Ford and General Motors, cellular phone service plans, movie
tickets, and admission to theme parks.
- Flexible Work Hours: Flexible work options offer
creative approaches for completing work while promoting balance
between work and personal commitments. These approaches involve use
of non-traditional work hours, locations, and/or job
- Penn Home Ownership Services: Penn offers a forgivable
loan for eligible employees interested in buying a home or
currently residing in West Philadelphia, which can be used for
closing costs or home improvements.
- Adoption Assistance: Penn will reimburse eligible
employees on qualified expenses in connection with the legal
adoption of an eligible child, such as travel or court fees, for up
to two adoptions in your household.
To learn more, please visit: https://www.hr.upenn.edu/PennHR/benefits-pay
To apply, visit https://wd1.myworkdaysite.com/en-US/recruiting/upenn/careers-at-penn/job/1500-Market-Street/Director--Clinical-Development--Gene-Therapy-Program-_JR00080723-1