Wayne State University is searching for an experienced Post-Doc
at its Detroit campus location.
Wayne State is a premier, public, urban research university located
in the heart of Detroit, Michigan where students from all
backgrounds are offered a rich, high-quality education. Our
deep-rooted commitment to excellence, collaboration, integrity,
diversity and inclusion creates exceptional educational
opportunities which prepare students for success in a global
Essential functions (job duties):
A new NIH-funded position is available for postdoctoral candidates
with experience in conducting drug screening assays, molecular
pharmacology experiments, and in vivo pharmacology studies. The
chosen candidate’s work will identify chemical compounds with
desirable biological activity profiles that are suitable for
escalation within the drug development process. The research fellow
is expected to work independently on assigned projects and
contribute substantially or wholly to their conception,
experimental designs, data generation and analysis, and
presentation. The postdoctoral fellow’s research will yield
reproducible findings pertaining to the biological actions of
drug-like molecules and communicate such findings in scientific
publications, patent filings, and grant submissions under the
guidance of the PI.
Lab webpage: www.gavandelab.com
A doctoral degree or equivalent (Ph.D., M.D., ScD., D.V.M., DDS
etc) in an appropriate field.
Experience with cell culture techniques, molecular biology
techniques (FP, ELISA, FRET, BRET, gel electrophoresis, enzyme
inhibition assays), biophysical techniques (SPR, ITC), tumor
xenograft models, and genetically modified mouse models.
Preference is shown for candidates with a strong track record in
cancer drug discovery/translational research. Previous experience
with experimental techniques for the characterization of PROTACs is
an additional plus.
Experience with target deconvolution using molecular pharmacology
& biophysical techniques.
Experience in conducting combination drug studies in cellulo and in
vivo for evaluating synergy and antagonism.
Demonstrable experience with spheroid (3D) viability assays or
other in vitro assays that mimic the human tumor microenvironment
(e.g. immune cell-based functional assays) is preferred.
Experience with nucleic acid techniques such as PCR, ChIP-seq,
RNAseq, Sanger Sequencing, and next-generation sequencing
techniques is a plus.
Ability to generate stably transfected cell lines for use in
high-throughput drug screening assays is preferred. Demonstrated
ability to effectively interact and communicate in
multidisciplinary project teams, including strong verbal, written
communication, and presentation skills.
Excellent organization and planning skills, the ability to work in
a fast-paced environment independently and as part of a team, and
strong motivation with a dedicated work ethic.
H18 - Pharmacy & Health Science
H1822 - Pharmaceutical Science
- Regular Employee
- Job type: Full Time
- Job category: Research
- Compensation type: Annual Salary
- Hourly rate:
- Salary minimum:
- Salary hire maximum:
Wayne State University requires all students, faculty and staff to
be fully vaccinated against COVID-19 with limited exceptions. Learn
more at: https://wayne.edu/coronavirus
Background check requirements:
- Number of openings: 1
- Reposted position: No
- Reposted reason: None (New Requisition)
- Prior posting/requisition number:
University policy requires certain persons who are offered
employment to undergo a background check, including a criminal
history check, before starting work. If you are offered employment,
the university will inform you if a background check is
Equal employment opportunity statement:
Wayne State University provides equal employment opportunities
(EEO) to all employees and applicants for employment without regard
to race, color, religion, sex, national origin, age, disability or
genetics. The university encourages applications from women, people
of color and other underrepresented people. Wayne State is an
affirmative action/equal opportunity employer.