Postdoctoral Research Associate

Postdoctoral Research Associate

About the Opportunity

The Engen Lab at Northeastern University seeks an enthusiastic postdoctoral researcher to start in Q1 2022. The research focus will be on the analysis of PROTACs, the recently emerged modality for pharmacological treatment of diseases. Studies will be conducted to learn how the structural and dynamic properties of the ternary complex formed between PROTAC, target protein, and E3 ligase are key for the efficiency of the ubiquitin transfer from ligase to protein of interest. The research is an important determinant for the degradation efficiency displayed by a specific PROTAC molecule. This fully-funded appointment is for 2 years, but could extend beyond that in some circumstances.

Responsibilities
The primary responsibility is to perform basic or applied research on the conformation and dynamics of proteins and protein complexes targeted by PROTACs, using existing theories and methods. They will assist the supervisor in the interpretation and publication of results and grants, assist in maintaining the laboratory, and may exercise functional supervision over supporting research staff. The postdoc is expected to write research papers, present research at meetings, contribute to research proposals, manage research data and software, and assist in mentoring students.

Qualifications

The candidate should have strong problem-solving skills and be highly motivated. The candidate must have a Ph.D. in chemistry, biochemistry, molecular biology, structural biology or a closely-related field. Previous experience with PROTACs, E3 ligases, ubiquitin-mediated degradation, or similar fields of study is necessary, as is a keen interest in proteins and how they function. A willingness to learn hydrogen/deuterium exchange mass spectrometry and other structural methods to augment their protein knowledge will be needed. The best candidates will have excellent communication, organization, and time management skills.

Preferred Qualifications

Previous experience with structural analysis (x-ray, NMR or cryoEM) of proteins is preferred. Prior experience with hydrogen/deuterium exchange mass spectrometry and/or proteomics is not required but would be valuable should it exist. Demonstrated proficiency in protein chemistry and protein biophysical analysis are preferred. Technical expertise in modern chromatography methodologies and techniques, good computer skills and data analysis experience are all desirable.

How to Apply
Applications should contain a cover letter briefly describing candidate's background and specific research interests, a full CV with a publication list, Ph.D. completion date, and the names and contact information for three references who might be contacted for recommendations. Review of applications will begin immediately.

The initial appointment is for two years, with the potential for extension depending on regular progress evaluation and continuation of funding.

Position Type

Research

Additional Information

Northeastern University is an equal opportunity employer, seeking to recruit and support a broadly diverse community of faculty and staff. Northeastern values and celebrates diversity in all its forms and strives to foster an inclusive culture built on respect that affirms inter-group relations and builds cohesion.

All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, religion, color, national origin, age, sex, sexual orientation, disability status, or any other characteristic protected by applicable law.

To learn more about Northeastern University's commitment and support of diversity and inclusion, please see www.northeastern.edu/diversity.


To apply, visit https://northeastern.wd1.myworkdayjobs.com/en-US/careers/job/Boston-MA-Main-Campus/Postdoctoral-Research-Associate_R103201



jeid-1a582ab027ac7748842811102d68cec6