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Research Scientist Protein Biochemist

Dartmouth College
New Hampshire, United States
Salary Not Specified
Posted Date
Oct 28, 2022
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Position Details

Position Information

Posting date


Closing date

Open Until Filled


Position Number


Position Title

Research Scientist Protein Biochemist

Department this Position Reports to

Dartmouth Institute of Biomolecular Targeting

Hiring Range Minimum

Please inquire

Hiring Range Maximum

Please inquire

SEIU Level

Not an SEIU Position

FLSA Status


Employment Category

Regular Full Time

Scheduled Months per Year


Scheduled Hours per Week



Location of Position

Hanover, NH
Remsen Level 3,

Remote Work Eligibility?

Onsite only

Is this a term position?


If yes, length of term in months.


Is this a grant funded position?


Position Purpose

The Dartmouth Institute for Biomolecular Targeting (bioMT) is seeking an experienced staff member to join its Core Facilities (Molecular Tools Core and Molecular Interactions and Imaging Core). The successful applicant will possess knowledge and hands-on experience on the design, production, and biophysical characterization of recombinant proteins. The Protein Biochemist will employ high-throughput approaches for construct design and protein expression and develop purification workflows involving multiple chromatographic methods (e.g., AP, IEC, SEC ). Previous experience with structural analysis (x-ray, or cryoEM) of proteins and/or in proteomics will be highly desirable. This person will actively contribute to and facilitate multidisciplinary research projects across the Dartmouth community. Other activities include but are not limited to, data collection and reporting, equipment maintenance, and training of bioMT investigators.


Required Qualifications - Education and Yrs Exp

PhD or equivalent combination of education and experience

Required Qualifications - Skills, Knowledge and Abilities
  • High competency in basic laboratory skills (pipetting, weighing, sterile technique, and recordkeeping), molecular cloning, and one or more of bacterial, insect, or mammalian cell culture.
  • Experience with protein purification methods and equipment.
  • Ability to learn, develop, and apply new techniques.
  • Ability to work independently and apply critical thinking and sound judgment.
  • Good organizational and time management skills.
  • Ability to multitask.
  • Ability to draft clear technical protocols.
  • Willingness to work with hazardous materials including biological agents and/or hazardous chemicals.
  • Knowledge of computers and software applications.
  • Excellent communication skills.
  • Willingness to work closely with diverse groups of students and research staff, including the ability to manage and resolve conflicts.
Preferred Qualifications

Four+ years of relevant research experience or the equivalent work in a laboratory is highly desirable

Department Contact for Cover Letter and Title

Andreia Verissimo

Equal Opportunity Employer

Dartmouth College is an equal opportunity/affirmative action employer with a strong commitment to diversity and inclusion. We prohibit discrimination on the basis of race, color, religion, sex, age, national origin, sexual orientation, gender identity or expression, disability, veteran status, marital status, or any other legally protected status. Applications by members of all underrepresented groups are encouraged.

Background Check

Employment in this position is contingent upon consent to and successful completion of a pre-employment background check, which may include a criminal background check, reference checks, verification of work history, and verification of any required academic credentials, licenses, and/or certifications, with results acceptable to Dartmouth College. A criminal conviction will not automatically disqualify an applicant from employment. Background check information will be used in a confidential, non-discriminatory manner consistent with state and federal law.

Special Instructions to Applicants

This position is funded by a grant. Continuation is based upon available funds.

All Dartmouth College employees, whether working on-site or remotely, are required to be up to date with vaccination against COVID -19 (or to have received an approved exemption from vaccination through the Office of Institutional Diversity and Equity). Please visit for details. Compliance with this requirement is a condition of employment. Failure to meet this condition of employment within the first 30 days may result in Dartmouth in its sole discretion ending employment.

Dartmouth College has a Tobacco-Free Policy. Smoking and the use of tobacco-based products (including smokeless tobacco) are prohibited in all facilities, grounds, vehicles or other areas owned, operated or occupied by Dartmouth College with no exceptions. For details, please see our policy.

Additional Instructions

Quick Link

Key Accountabilities


  • Works collaboratively with core facility staff, faculty, scientists, and graduate students from across the Dartmouth community to express and purify recombinant proteins for use in research projects.
  • Independently designs optimal constructs for protein production in E. coli, HEK293, and Sf9/Hi5 cells.
  • Independently optimizes expression conditions and develops purification protocols for diverse protein targets.
  • Develops proficiency in laboratory equipment for protein expression, purification, and characterization, including AKTA systems, centrifuges, and a variety of analytical instruments.
  • Gains experience with diverse biochemical and biophysical techniques, including SPR, ITC, Fluorescence polarization and X-ray Crystallography.
  • Supports proteomics projects by helping with sample preparation, LC-MS/MS applications, and data analysis.
  • Prepare and optimize protein samples for structure determination by cryoEM to support structural biology research projects.
  • As needed, supports eukaryotic cell culture services, including culture maintenance and transfection.
  • Troubleshoots and recommends solutions to problems associated with experimental design, procedures, and equipment.
Percentage Of Time



Data Collection/Preparation
  • Collects, analyzes, and interprets data resulting from expression and purification experiments.
  • Performs literature searches to develop information of relevance to current projects.
  • Prepares appropriate and understandable representations of data such as sequence files, graphs, charts, etc.
  • Participates in the preparation of annual reports.
  • Presents data at laboratory meetings, departmental retreats, and scientific conferences.
  • Contributes to the preparation of scientific manuscripts by drafting portions of the text, preparing graphs, tables, and charts, etc. as needed.
Percentage Of Time



  • Adheres to laboratory safety requirements including general, biological, and chemical/hazardous waste safety disposal methods.
  • Develops SOPs and other documentation for common procedures and methods.
  • Develops and tracks quality-assurance and quality-control metrics.
  • Maintains hardcopy and computerized records associated with laboratory activities.
Percentage Of Time



  • Provides training in laboratory methods, procedures, and techniques to multiple levels of scientific investigators (graduate students, post-doctoral fellows, staff scientists and faculty).
  • Develops instructional materials as needed.
Percentage Of Time




Demonstrates a commitment to diversity, inclusion, and cultural awareness through actions, interactions, and communications with others.


Performs other duties as assigned.
Supplemental Questions

Required fields are indicated with an asterisk (*).

  1. * How did you hear about this employment opportunity?
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    • Chronicle of Higher Education
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    • Dartmouth College Employment Website
    • Glassdoor
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    • Recruit Military
    • Prospanica
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    • Other (Please specify below)
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  2. If you answered 'Other' to the above question, please specify here

    (Open Ended Question)

Documents Needed to Apply
Required Documents
  1. Cover Letter
  2. Curriculum Vitae
Optional Documents
  1. Additional Document #1

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