We are seeking a highly motivated motivated postdoctoral trainee to
work in Dr. Cieslik’s laboratory to study changes in the
extracellular matrix and inflammation in the aging heart. In our
previous work, we demonstrated a therapeutic response to Glycine
(Gly) and N-Acetyl Cysteine (NAC) dietary supplementation (GlyNAC)
in old male mice. The old mice demonstrated a striking improvement
in diastolic function, left atrial volume, and left ventricular
diastolic pressure with GlyNAC dietary supplementation that was not
seen with NAC alone. GlyNAC improved mitochondrial function and
carbohydrate metabolism. However, the most striking change was a
decrease in inflammatory mediators (IL-6), an increase in
anti-inflammatory IL-10, and reduced leukocyte infiltration into
the heart. Further investigation of the mechanism by which GlyNAC
prevents and reverses diastolic dysfunction in old male and female
mice will be the focus of postdoctoral trainee research.
- Participate in literature searching.
- Design and conduct experiments.
- Co-authors publications.
- Present data in seminars and meetings.
- MD or Ph.D. in Basic Science, Health Science, or a related
- No experience.
- Experience in handling mice.
- Experience with RNA and protein extraction and detection.
- Experience with culturing primary cells.
- Background in immunology or cardiac physiology is a plus.
- Good communication and writing skills.
Please send your CV, a cover letter summarizing your experience,
and contact information of three references to email@example.com
Baylor College of Medicine is an Equal Opportunity/Affirmative
Action/Equal Access Employer.
CA; CH; PD