Dr. Cieslik’s laboratory is seeking a highly motivated postdoctoral trainee to study changes in the extracellular matrix and inflammation in the aging heart. In our previous work, we demonstrated a therapeutic response to Glycine (Gly) and N-Acetyl Cysteine (NAC) dietary supplementation (GlyNAC) in old male mice. The old mice demonstrated a striking improvement in diastolic function, left atrial volume, and left ventricular diastolic pressure with GlyNAC dietary supplementation that was not seen with NAC alone. GlyNAC improved mitochondrial function and carbohydrate metabolism. However, the most striking change was a decrease in inflammatory mediators (IL-6), an increase in anti-inflammatory IL-10, and reduced leukocyte infiltration into the heart. Further investigation of the mechanism by which GlyNAC prevents and reverses diastolic dysfunction in old male and female mice will be the focus of postdoctoral trainee research.
Due to the nature of the research and potential contamination, this position is not suitable for smokers (mold spores from tobacco can transfer to clothes and contaminate tissue culture).
- Participates in literature searching.
- Designs and conducts experiments.
- Co-Authors publications.
- Presents data in seminars and meetings.
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience.
- Experience in handling mice.
- Experience with RNA and protein extraction and detection.
- Experience with culturing primary cells.
- Background in immunology or cardiac physiology is a plus.
- Good communication and writing skills.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
CA; CH; PD