Postdoctoral position in cancer research
The Hofmann laboratory in the Department of Endocrine Neoplasia studies the molecular mechanisms of acquired resistance to targeted therapies in aggressive thyroid cancers, in particular anaplastic thyroid cancer (ATC). We have recently identified a number of pathways and relevant molecules inducing resistance to kinase inhibitors. Funded projects include studying the role of specific EMT drivers and other transcription factors in cell growth and metastasis and interrogating the tumor-stroma interface. We are using human/mouse cell lines and genetically engineered mouse models of ATC to test the efficacy of novel drugs in vitro and in vivo that might prevent resistance to therapies.
We are seeking applicants for a post-doctorate fellowship in the areas of cellular and molecular biology. The fellow will be using in vitro and in vivo models to study the function of certain genes and secondary mutations that induce thyroid cancer cell growth and metastasis. Models include 2D and 3D culture systems and GEMM. In addition, we expect the postdoctoral fellow to gain expert-level skills in CyTOF, scRNA-Seq, other omics, and work in consultation with in house computational scientists. The fellow will develop a new independent project that will extend the studies into clinically relevant and fundable areas. The fellow is expected to write and prepare research presentations, manuscripts and grant proposals
The applicant must have a minimum of a Ph.D. degree in biochemistry/cell/molecular biology, have at least three years of experience in basic laboratory techniques such as tissue culture, molecular analysis of DNA, RNA, and protein, and tumor models. Preparing samples for next-generation sequencing is recommended. A minimum of two publications is expected.
The appointment is immediately available. Initial appointment is for one year and is renewable.
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