The HeczeLab believes that the development of the next-generation
of cell therapies will be based on in-vivo (inside the body)
genetic engineering of cells which can overcome the immune escape
mechanisms employed within the tumor microenvironment to safely and
effectively cure patients with cancer. The post-doctoral associate
will be part of an energetic team within the combined translational
laboratories of the Advance Innate Cell Therapy Center of Texas
Children’s and the Center for Cell and Gene Therapy of Baylor
College of Medicine. This position will focus on developing evasion
strategies to overcome immune escape of tumors. Specific targets to
accomplish this goal are informed by our two ongoing clinical
trials treating patients with CAR T cells. The project will
implement tumor triggered regulatory circuits to protect the
engineered cells from exhaustion and enhance their survival with
the tumor microenvironment.
- Design and conduct the experiments related to the project with
the help of the mentor and other team members of the Heczey
- Redirect effector lymphocytes to eliminate cancer cells with
viral and nonviral vectors including CRISPR-Cas9.
- Evaluate the functional properties of these engineered cells in
- Engineer and test effector lymphocytes in invitro and cancer
bearing animal models.
- Analyze the data and present the evolving results at weekly
laboratory meetings and research seminars of the Center for Cell
and Gene Therapy.
- Record details of the experiments and the findings in
electronic laboratory notebook.
- Ph.D. in Basic Science, Health Science, or a related
- Great fund of knowledge of tumor immunology principles.
- Understanding basic genetic engineering techniques
(transfection, retroviral / lentiviral transduction, transposition,
- Viral particle assembly.
- Protein purification.
- Excellent aseptic cell culture technique.
- Enthusiasm and a willingness to learn in a fast-pace,
- Strong organizational skills, record keeping, and interpersonal
communication skills (verbal and written).
Baylor College of Medicine is an Equal Opportunity/Affirmative
Action/Equal Access Employer.
CA; CH; PD