Postdoctoral Associate - Human/Mouse Skeletal Genetics

Employer
Baylor College of Medicine
Location
Texas, United States
Salary
Salary Not Specified
Start date
May 18, 2021

View more

Position Type
Faculty Positions, Health & Medicine, Medicine, Other Health & Medicine, Science, Technology & Mathematics, Biology & Life Sciences, Other Science & Technology, Social & Behavioral Sciences, Human Development & Family Sciences
Employment Type
Full Time


Summary

Dr. Lee pioneered the translation of gene discoveries into therapies for both rare and common diseases. He identified the first human mutations in dwarfism (in COL2A1) and Marfan syndrome (in Fibrillin), and then in the master transcriptional factors (RUNX2 and LMX1B) that regulate these matrix proteins during skeletal differentiation and patterning. He then showed how dysregulation of post‐translational modification of collagens causes osteogenesis imperfecta (OI) leading to the discovery of over 18 new genetic causes of OI. He showed that increased TGFb signaling is a common driver in OI and he is testing this in a clinical trial by the NIH Brittle Bone Disorders Consortium. Studying matrix-cell signaling in bone, he identified WNT1 as the key WNT regulating human bone mass in dominant, early-onset osteoporosis and in recessive OI, co-led the first clinical trial of anabolic therapy in OI, and identified Notch requirements in bone homeostasis and its dysregulation as a driver of osteosarcoma and breast cancer metastasis. He developed a gene therapy approach for the osteoarthritis in chondrodysplasias and this is now licensed for testing in the first human in vivo gene therapy trial in age-related osteoarthritis. In the area of genomic medicine, he is leading the application of whole genome and RNA sequencing technologies to the evaluation of undiagnosed disease in the NIH Undiagnosed Diseases Network.

https://www.bcm.edu/people-search/brendan-lee-25203
https://www.bcm.edu/research/labs-and-centers/faculty-labs/brendan-lee-lab
https://www.bcm.edu/research/labs-and-centers/research-centers/center-for-skeletal-medicine-and-biology

We are seeking a Postdoctoral Associate with experience in preferably in mouse genetics and skeletal biology (although not required). The position will perform mouse genetic and cell biological studies into the mechanisms of how mutations causing human skeletal dysplasias affect bone, cartilage, and tendon development and homeostasis. Mouse genetics as well as induced pluripotent stem cells will be used to model human mutations. Current disease models under study include brittle bone disease or Osteogenesis imperfecta. The position will study impact of these mutations on osteoblast, osteoclast, chondrocyte, and tenocyte development and homeostasis. In addition, the Postdoctoral Associate will study how matrix mutations alter signaling to progenitor or skeletal stem cells.

Job Duties
  • Plans, directs and conducts specialized and advanced research experiments.
  • Evaluates and analyzes data.
  • May establish new research protocols and procedures.
  • Summarizes research findings and publish results in research journals.
  • May be responsible for laboratory operations.
  • May supervise research staff.


Minimum Qualifications
  • MD or Ph.D. in Basic Science, Health Science, or a related field.
  • No experience required.


Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

7069

CA; CH

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