The St-Pierre Lab, (stpierrelab.com) develops and applies new tools for imaging the brain in animal models with cellular and subcellular resolution. We are particularly interested in genetically encoded voltage indicators (GEVIs) which are biosensors based on fluorescent proteins that reports voltage as changes in brightness. GEVI therefore promise to enable non-invasive monitoring of neural electrical activity by imaging rather than by traditional electrophysiological methods. These indicators have already been applied in Drosophila and in rodent brain slices but need further improvement to be of broad utility in mammalian in vivo models.
We are seeking a new energetic team member to lead our efforts to characterize and apply this exciting new technology in vitro and in vivo. Detailed characterization of these tools requires electrophysiology, hence this current position. An ideal candidate is someone who has experience with electrophysiology in dissociated neurons and brain slices. This position provides exciting opportunities for candidates to develop new skills in two-photon voltage imaging, protein engineering, and synthetic biology.
- Conduct research projects, both independently and with others.
- Purchase, setting up and maintaining equipment necessary to conduct research.
- Teach techniques, procedures, and experimental design to other members of the lab.
- Communicate research results during our group meetings, and in
local/national/international research meetings and
- Master's degree in Basic Science or a related field. Experience in lieu of degree will not be accepted.
- Three years of relevant experience typically as a Research Assistant, Research Technician or Postdoctoral Fellow/Associate.
- Ability to perform electrophysiology in dissociated neurons and in brain slices.
- Ability to dissect rat cortical, hippocampal neurons, or both.
- Ability to maintain an electrophysiology rig.
- Technical skills that are desired by not required.
- Ability to express transgenes in neurons of brain slices using viruses and/or in utero electroporation.
- Experience with imaging neural activity (e.g. voltage or calcium) in brain slices or in vivo, using 1P and/or 2P imaging.
- Ability to code using Matlab, Python, or other languages.
Please include a recent CV and the contact information for at least 2 references who can attest to your accomplishments and your potential as a scientist. Please include your Ph.D. advisor as one of the two references.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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