Will work within a multi-disciplinary research team working collaboratively to determine the molecular drivers of brain tumor initiation and progression. Primarily focuses on chromatin regulation in pediatric high grade glioma (pHGG), a class of rare but aggressive brain tumors harboring frequent mutations in genes encoding histones (eg. H3K27M and H3G34R/V). Future studies will employ a suite of genetic and chemical tools to reveal how chromatin dysregulation promotes pHGG tumorigenesis on a mechanistic level and will be aimed at identifying new therapeutic targets for childhood cancers with no cure. We will also apply high-throughput pharmacogenetic screens to identify novel combinatorial therapies to overcome acquired and intrinsic drug resistance in brain tumors.
- Plans, directs and conducts specialized and advanced research experiments.
- Evaluates and analyzes data.
- Establishes new research protocols and procedures.
- Summarizes research findings and publish results in research journals.
- Responsible for laboratory operations.
- Supervises research staff.
- Ph.D. (or equivalent) in biomedical sciences, highly motivated and career-oriented.
- Strong background in cancer biology, molecular biology, and genomics.
- Previous experience in animal models and experience with stereotactic rodent surgery is highly preferred.
- Previous experience in NGS technologies such as RNAseq, chIP-seq, ATACseq is ideal, but not required.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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