We use predominately mammalian in vivo experimental systems. One area of investigation is our longstanding interest in understanding the pathogenic mechanisms of, and developing therapeutic approaches for, the microsatellite expansion disorder, myotonic dystrophy (DM1) in which disrupted alternative splicing is a predominant pathogenic mechanism.
A second area of investigation is the function of conserved alternative splicing events during heart and skeletal muscle postnatal development. We identified fetal-to-adult protein isoform transitions that are required for normal function in adult mice using CRISPR-mediated removal of alterantive exons to force expression of only the fetal isoforms.
- Plans, directs and conducts specialized and advanced research experiments.
- Evaluates and analyzes data.
- May establish new research protocols and procedures.
- Summarizes research findings and publish results in research journals.
- May be responsible for laboratory operations.
- May supervise research staff.
- Education Required: MD or Ph.D in Basic Science, Health Science, or a related field.
- Experience Required: None Required.
- Certification/Licenses/Registration: None Required.
- Alternative splicing affected in DM1.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
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