Post-Doctoral Fellow/Lab Manager, Surgery

Position Summary

A postdoctoral fellow or lab manager position is available in the laboratory of Dr. Anna Blumental-Perry. The laboratory is using exposure to cigarette smoke (CS) and to nicotine as model systems for environmentally induced physiological stressors in exposed cells, animals and humans. We interrogate two main research directions:

(1) Stress induced mitochondria-nucleus communication mediated by small non-coding RNAs.

(2) Cigarette-smoke induces endoplasmic reticulum stress response ( ERSR ), with emphasis on redox signaling function of post-transnationally oxidized Protein Disulfide Isomerase ( PDI ), and identification of specific components of ERSR that are involved in the pathogenesis of chronic obstructive pulmonary disease ( COPD ).

The lab is located in the Department of Biochemistry in the downtown campus with access to cutting­ edge resources and core facilities. The lab currently utilizes multidisciplinary approaches including cell and molecular biology, advanced microscopy, protein purification with in vitro reconstitution assays, animal models of disease, and bioinformatics.

The laboratory is new. The candidate is expected to help with initial laboratory setting, which should be followed promptly by advanced biomedical research, using a variety of approaches and techniques that include wet-lab experiments as well as computational analysis. The selected candidate must be highly motivated, and able to take initiative; work well independently but closely with PI, and with members of the research group. The postdoctoral fellow will be provided opportunities and support for independent grant writing and career improvement.

Outstanding Benefits Package
Working at UB comes with benefits that exceed salary alone. There are personal rewards including comprehensive health and retirement plan options. We also focus on creating and sustaining a healthy mix of work, personal and academic pursuit – all in an effort to support your work-life effectiveness. Visit our benefits website to learn about our benefit packages .

About UB
The University at Buffalo is SUNY’s most comprehensive public research university, and an outstanding place to work. UB amplifies ambition for faculty and staff by offering endless possibilities to achieve more. Here, people from all backgrounds and cultures challenge and inspire each other to discover, learn and succeed. Dedicated staff and engaged faculty collaborate to further knowledge and understanding, and develop tenacious graduates who are valued for their talents and their impact on global society. Visit our website to learn more about the University at Buffalo .

As an Equal Opportunity / Affirmative Action employer, the Research Foundation will not discriminate in its employment practices due to an applicant’s race, color, religion, sex, sexual orientation, gender identity, national origin and veteran or disability status.

Minimum Qualifications

The candidate with a PhD is required.

Proficiency in the following techniques are encouraged and will be required during research :

Cell culture techniques, including isolation of primary cells
• Animal handling
• Protein isolation and Western blot analysis,
• Familiarity with cellular fractionation techniques, including mitochondria and nucleus isolations
• DNA, RNA isolation, and electrophoresis,
• RT-qPCR, Northern blot analysis
• Basis cloning techniques, including working with bacteria, ligations, and site directed mutagenesis
• Basic microscopy, staining techniques, image acquisition, processing and analysis
• Excel, Power Point and Microsoft office, and Photoshop proficiency, including basic statistical and image analyses
• Proficiency with basic bioinformatics is highly desirable

Preferred Qualifications

Candidates familiar with advanced RNA analysis techniques such as transcription, translation and degradation rates, RNA editing, and RNA -protein interactions; as well as candidates familiar with analysis of mitochondrial function and activities, will be given priority.

For more information, click the "How to Apply" button.

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