Post Doc -Cryo-Electron Microscopy of Membrane Proteins



Post-Doctoral Position in Cryo-Electron Microscopy of Membrane Proteins

Post-Doctoral Fellow Program in Biomolecular Therapeutics

Center for Biomolecular Therapeutics

University of Maryland School of Medicine, Baltimore MD

The Hong ( http://www.medschool.umaryland.edu/hong-lab ) and Weber ( https://www.medschool.umaryland.edu/profiles/Weber-David/ ) laboratories are recruiting a post-doctoral fellow with an interest in using high-resolution single particle cryo-electron microscopy (cryoEM) to investigate the structural biology of membrane proteins implicated in cancer and infectious diseases. The CBT houses a new 200 keV Thermo Fisher Talos Arctica cryoEM microscope equipped with a Gatan K3 direct electron detector and a second 200 keV Thermo Fisher Glacios cryoEM microscope equipped with a Falcon III direct electron detector. A 120 keV FEI Tecnai T12 TEM equipped with a CCD camera is available for negative stain imaging as are 300 keV systems at the nearby NCI National cryoEM center.

The CBT is located in Rockville MD (http://www.medschool.umaryland.edu/cbt/). In addition to the latest cryoEM facilities at CBT, the fellow will have access to tools in NMR (950, 900, 800, 600, 500, 400 MHz), X-ray crystallography, small angle X-ray scattering, mass-spectrometry and computational biology. The CBT will provide the fellow with opportunities to work closely in collaboration with scientists in industry and in national labs located nearby (i.e., NIH, NIST).

Applicants who have received their PhD or MD/PhD degree should submit a single PDF file containing a short cover letter (no more than one page), a detailed curriculum vitae, contact information for three references, and up to 5 reprints of representative first authorship publication(s) to Charles C. Hong, MD, PhD (charles.hong@som.umaryland.edu; Professor, UMB) and David J. Weber, PhD (dweber@som.umaryland.edu; Professor, UMB, and Director of CBT). Highly qualified applicants will be contacted soon after their application is received to investigate specific fellowship opportunities in the CBT.

The University of Maryland, Baltimore is an Equal Opportunity, Affirmative Action employer. Minorities, women, individuals with disabilities and protected veterans are encouraged to apply.

Qualifications :

Expertise in one or more of the following areas is required:

1. structural biology (preferably cryoEM)

2. molecular biology including handling of eukaryotic cell lines for protein production

3. membrane protein chemistry

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