Postdoctoral Associate (63818)

The Caglayan lab in the Department of Biochemistry and Molecular Biology, University of Florida seek an outstanding individual with Ph.D. training in biochemistry and/or structural biology to study the DNA repair. The NIH-funded research project will focus on studying genome stability, DNA repair, and DNA damage processing.

Duties will include:

Supporting projects through original research, collaboration with other team members, interpreting and critically evaluating primary literature; collection and analysis of data; and maintaining a complete, accurate, and up-to-date lab notebook; preparing and editing manuscripts for publication as well as applications for grants; attending an annual meeting to disseminate research findings and progress; supervising and training of graduate students (PhD and Master's level) and undergraduates. Applicants should have excellent communication and problem-solving skills and the ability to work flexible hours depending on specific experiments.

The Caglayan group is in both the Department of Biochemistry and Molecular Biology, and UF Health Cancer Center with investigators renowned for their contributions to the area of biochemistry and cancer biology. The lab utilizes a multi-disciplinary approach to investigate complex biological questions using X-ray structure (structure-function studies), biochemistry, enzymology, and molecular biology.

Selected Publications

1. Caglayan M. (2020) Pol β gap filling, DNA ligation and substrate-product channeling during base excision repair opposite oxidized 5-methylcytosine modifications. DNA Repair 95: 102945.
2. Caglayan M. (2020) The ligation of pol β mismatch insertion products governs the formation of promutagenic base excision DNA repair intermediates. Nucleic Acids Research 48: 3708 – 3721.
3. Caglayan M. (2020) Pol μ ribonucleotide insertion opposite 8-oxodG facilitates the ligation of premutagenic DNA repair intermediate. Scientific Reports 10: 940.
4. Caglayan M. (2019) Interplay between DNA polymerases and DNA ligases: Influence on substrate channeling and the fidelity of DNA ligation. Journal of Molecular Biology 31: 2068 – 2081.
5. Caglayan M. and Wilson S.H. (2018) Pol μ dGTP mismatch insertion opposite T coupled with ligation reveals a promutagenic DNA intermediate during double strand break repair. Nature Communications 9: 4213.
6. Caglayan M., Prasad R., Krasich R., Longley M.J., Kadoda K., Tsuda M., Sasanuma H., Takeda S., Tano K., Copeland W.C., Wilson S.H. (2017) Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts. Nucleic Acids Research 17: 10079 – 10088.
7. Caglayan M., Horton J.K., Da-Peng D., Stefanick D.F., Wilson S.H. (2017) Oxidized nucleotide insertion by pol β confounds ligation during base excision repair. Nature Communications 8: 14045.
8. Caglayan M., Horton J.K., Prasad R., Wilson S.H. (2015) Complementation of aprataxin deficiency by base excision repair enzymes. Nucleic Acids Research 43: 2271 – 2281.

Minimum Requirements:

PhD in a related discipline.

Preferred Qualifications:

The candidate should have experience in biochemistry (protein purification) and enzymology (rapid quench, enzyme kinetics). Previous working experience with evidence of experimental skills with DNA repair proteins is preferred.

Advertised Salary

The salary for this position is commensurate with experience as determined by NIH guidelines

To apply, please upload Curriculum Vitae, a statement of research interest, and contact information for three (3) letters of recommendations. Should you have any questions regarding this position, please contact Dr. Melike Caglayan at caglayanm@ufl.edu .

The final candidate will be required to provide official transcript to the hiring department upon hire. A transcript will not be considered "official" if a designation of "Issued to Student" is visible. Degrees earned from an education institution outside of the United States are required to be evaluated by a professional credentialing service provider approved by National Association of Credential Evaluation Services (NACES), which can be found at http://www.naces.org/

If an accommodation due to a disability is needed to apply for this position, please call 352-392-2477 or the Florida Relay System at 800-955-8771 (TDD). Hiring is contingent upon eligibility to work in the US. Searches are conducted in accordance with Florida's Sunshine Law.

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