Postdoctoral Fellowship (Membrane Protein Structural Biology)

Posting Details

Job Code/Title Position Number P00001 Working Title Postdoctoral Fellowship (Membrane Protein Structural Biology) Department Medicinal Chemistry Organizational Overview

At VCU, we Make it Real through learning, research, creativity, service and discovery — the hallmarks of the VCU experience. A premier, urban, public research university nationally recognized as one of the best employers for diversity, VCU is a great place to work. It’s a place of opportunity, where your success is supported and your career can thrive. VCU offers employees a generous leave package, career paths for advancement, competitive pay, and an opportunity to do mission-driven work.

Recruitment Pool All Applicants Anticipated Hiring Range minimum $47,476 Campus MCV Campus Position Type Post Doc Hours/Week Normal work days Normal work hours Job Category Research Does this position provide patient or clinical services to the VCU Health System? No Does this position require a pre-placement medical assessment? No Is any portion of this position grant-funded? Yes - Continuation of this position depends on funding of the grant. Sensitive Position No Resource Critical Yes Description of the Job

We have successfully determined the first atomic resolution structure of a patch of native cell membrane lipid bilayer using our prototype NCMN system. The new technology will be used for structure determination of our selected biologically or bio-medically important membrane proteins or complexes in our lab or in collaboration with several excellent collaborators including members of National Academy of Sciences and Nobel Laureates.

The Department of Medicinal Chemistry is seeking a highly motivated scientist who is interested in membrane protein structural biology and structure-based drug discovery. The incumbent will assist with developing revolutionary technology for membrane protein research, especially for high-resolution structure determination with single particles cryo-EM.

Required Qualifications

-PhD in biochemistry, biophysics, and/or structural biology with experience in protein biochemistry.
-The successful candidate will work in a highly collaborative research environment, focusing their research on the structural analysis of selected model membrane proteins with an emphasis on technological development.
-Work closely with a highly collaborative group of scientists whose expertise includes organic synthesis, protein production purification, assay development, NMR spectroscopy, X-ray crystallography, and cryo-electron microscopy (cryo-EM).
-The incumbent will be responsible for the production of high-quality membrane protein samples to enable structural and functional
-A proven track-record in optimizing the expression and purification of challenging
proteins is therefore highly desirable.
-Proficiency in X-ray crystallography and/or cryo-EM methods is strongly preferred.
-Must be driven to succeed on challenging research projects that aim to explore the structural basis of membrane protein activity.

Preferred Qualifications Job Open Date 07/23/2019 Remove from posting on or before Open Until Filled No Special Instructions to Applicants

For immediate consideration, please send a cover letter, CV and at least two reference letters to Dr. Youzhong Guo. Email:

Additional Information

Many membrane proteins are important drug targets. We are pioneering a new technology development for membrane protein structure biology and related drug discovery and work on several biomedically important membrane proteins. Furthermore, we also collaborate with several excellent scientists, some of them are members of National Academy of Sciences or Nobel Prize Laureates. Working in a multidisciplinary environment, the successful candidate will have the advantage of learning from other experts to lead and develop his/her own unique research areas.

-Must be eligible to work in the U.S.

Quick Link Supplemental Questions

Required fields are indicated with an asterisk (*).

  1. * Please list your work experience after earning your Ph.D. (postdoctoral fellowship, National Lab, Academic Appointment, or Industry):

    (Open Ended Question)

Optional & Required Documents
Required Documents
  1. Curriculum Vitae (CV)
Optional Documents
  1. Resume
  2. Cover Letter/Letter of Application

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